The 20 year evolution of dobutamine stress cardiovascular magnetic resonance

Over the past 20 years, investigators world-wide have developed and utilized dobutamine magnetic resonance stress testing procedures for the purpose of identifying ischemia, viability, and cardiac prognosis. This article traces these developments and reviews the data utilized to substantiate this relatively new noninvasive imaging procedure

Genome-wide Association Study of Response to Methotrexate in Early Rheumatoid Arthritis Patients

Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two consortia to carry out a genome-wide study of response to MTX in 1424 early RA patients of European ancestry. Clinical endpoints were change from baseline to 6 months after starting treatment in swollen 28-joint count, tender 28-joint count, C-reactive protein and the overall 3-component disease activity score (DAS28). No single nucleotide polymorphism (SNP) reached genome-wide statistical significance for any outcome measure. The strongest evidence for association was with rs168201 in NRG3 (p = 10‾⁷ for change in DAS28). Some support was also seen for association with ZMIZ1, previously highlighted in a study of response to MTX in juvenile idiopathic arthritis. Follow-up in two smaller cohorts of 429 and 177 RA patients did not support these findings, although these cohorts were more heterogeneous

The prolonged activity of the mineral fertilizers upon yield of pady and white rice

In a stationary field experiment by the "Cade" method at the locality "Bosevica" on an alluvial soil, pre-crop rice, the direct (3 year application) and prolonged activity (1 year application, 2 year prolonged activity) of the mineral fertilizers was investigated at rice variety monticeli during the 2000/02

Prolonged activity effects of mineral fertilizers on white rice yield and rice protein content

The yield, total and protein nitrogen content as well as proteins in paddy and white rice grain have been observed under influence of direct and prolonged activity of mineral fertilizers. Namely, in a stationary field trial by the "Cade" method on an alluvial soil, precrop rice, direct and prolonged activity of four quantities nitrogen and two quantities phosphorus and potassium fertilizer were investigated in rice variety Monticelli (3 years of application and 1 year of application, 2 years prolonged activity). The variants in the trials were the following: Control - untreated; I-N45P45K45, II - N90P90K90, III - N120P90K90 and IV - N150P90K90. The fertilizers (NPK 15:15:15 and Uras 27%) were applied pre-plant. Results obtained from the investigations show that there were no significant differences in the content of fractions during the paddy whitening between the variants - direct activity and the variants - prolonged activity of the mineral fertilizers, as well as in the various years of investigation. The best average white rice yield (whole grains) is achieved in the variant I-N45P45K45 (both in direct fertilizer activity and prolonged activity). The total nitrogen, protein, and paddy and white rice protein content vary in various years of investigations as well as in the investigated variants themselves. The highest total nitrogen, protein nitrogen and protein content is obtained in the trial year

The effect of NPK, Mg and B on the yields, morphological characteristics and quality characteristics of industrial tomatoes

In the two year period from 1994 to 1995 field experiments with industrial tomatoes were done on the test fields at the Agricultural Institute in Strumica, R. of Macedonia. The tests were carried out on alluvial soil, with low lime content, humus nitrogen (N), moderate aviable phosphorus (P) and potassium (K). The subject of the experiment was the effect of NPK, Mg and B fertilization on yield, morphological and chemical characteristics of the industrial tomato variety AT-70-14. It was seen that Mg and B influenced the yield of this kind tomato. The economic effect of fertilization was highest with the variant with N100 P100 K150 + 1% Mg +0.5% B

Prolonged activity effects of mineral fertilizers on some morphological - biological and productive properties in rice

The investigations were carried out in a stationary field trial by the "Cade" method on an alluvial soil, pre-crop rice. DIrect (3 years of application) and prolonged activity (1 year of application, 2 years prolonged activity) of mineral fertilizers were investigated art rice variety Monticelli. The variants in the trials were as follows: Untreated - control, I-N45P45K45. II N90P90K90, III N120P90K90 and IV - N150P90K90. The fertilizers (NPK 15:15:15 and Uras 27%) were applied pre-plant. Obtained results show that the fertilizers in the investigated variants show no significant prolonged pre plant. Obtained results show that the fertilizers in the investigated variants show no significant prolonged activity in the second and the third trial year. Namely, the number of productive tillers per m^2, average stem height and panicle length of the plants in both variant. The longest panicle oof the fertilized variants- direct activity is achieved by the plants in variant IV-18.98 sm, and of the untreated variants -prolonged activity in the variant III-18.42 sm. In the variants with a prolonged fertilizer activity no significant higher average values for the mass of 1.000 grains and hectolire mass were obtained in comparison with the values obtained from the fertilized variants - direct activity. The highest average number of grains per panicle of the fertilized variants- direct activity is achieved in the variant III - 134.72, and of the variants with prolonged fertilizer activity in the variant II - 142.14 grains

Grbavcic et al_Monitoring.p65

The aim of our investigation was to understand the formation of SO 4 as a function of SO 2 and other constituents of atmosphere that affect this conversion (such as water content, particle concentration, intensity of sunlight, trace metals, etc). For this purpose, air quality monitoring was conducted at three different locations (one in urban and two in rural area). Results of this investigation are presented and discussed in this paper